Assessment of efficacy, safety, and tolerability of 4-n-butylresorcinol 0.3% cream: an Indian multicentric study on melasma

NT Madan Mohan, A Gowda, AK Jaiswal… - Clinical, cosmetic and …, 2016 - Taylor & Francis
… human tyrosinase inhibitory activity of 4-n-butylresorcinol … compound for the management
of pigmentation disorders. In … study, 4-n-butylresorcinol 0.3% cream was very effective and …

4nbutylresorcinol enhances proteolytic degradation of tyrosinase in B16F10 melanoma cells

SJ Lee, YH Son, KB Lee, JH Lee… - … Journal of Cosmetic …, 2017 - Wiley Online Library
hyperpigmentation disorders and for whitening skin after … In clinical studies, topical application
of 4-n-butylresorcinol showed … 4-n-butylresorcinol is a well-known tyrosinase inhibitor 26. …

Efficacy of liposome‐encapsulated 4nbutylresorcinol and resveratrol cream in the treatment of melasma

SH Kwon, JH Yang, JW Shin, KC Park… - Journal of Cosmetic …, 2020 - Wiley Online Library
… have been shown to inhibit UV-induced pigmentation.9, 10 Since … tyrosinase levels, we
evaluated efficacy and safety of a … , 4nBR, a strong tyrosinase inhibitor, could work in combination …

4nbutylresorcinol dissolving microneedle patch for skin depigmentation: a randomized, double‐blind, placebo‐controlled trial

S Kim, H Yang, M Kim, JH Baek, SJ Kim… - Journal of cosmetic …, 2016 - Wiley Online Library
… ) and who had facial hyperpigmentation were selected to test … to melanocytes efficiently
thereby inhibiting tyrosinase activity in … 4-n-butylresorcinol patch compared with traditional cream

[HTML][HTML] Inhibition of human tyrosinase requires molecular motifs distinctively different from mushroom tyrosinase

T Mann, W Gerwat, J Batzer, K Eggers… - Journal of Investigative …, 2018 - Elsevier
tyrosinase inhibitors have been identified, but most of those … and most effective way to treat
cutaneous hyperpigmentation … efficacy when incorporated into topical products. Almost all of …

[HTML][HTML] Skin depigmenting agents in anti-aging cosmetics: A medicinal perspective on emerging ingredients

DISP Resende, MS Ferreira, JMS Lobo, E Sousa… - Applied Sciences, 2022 - mdpi.com
… 4-Butylresorcinol, also known as rucinol, is a highly effective … use of a 0.3% 4-n-butylresorcinol
cream instead of the widely … senile hyperpigmentation on the forearm were treated twice …

[HTML][HTML] Comparative Studies on the Photoreactivity, Efficacy, and Safety of Depigmenting Agents

S Mota, GP Rosa, MC Barreto, J Garrido, E Sousa… - Pharmaceuticals, 2023 - mdpi.com
… , 4BR was the most effective compound inhibiting tyrosinase, … aimed at addressing
hyperpigmentation in the cosmetics … are the most potent and photostable tyrosinase inhibitors, …

[HTML][HTML] Natural and bioinspired phenolic compounds as tyrosinase inhibitors for the treatment of skin hyperpigmentation: Recent advances

L Panzella, A Napolitano - Cosmetics, 2019 - mdpi.com
… of the most common approaches for control of skin pigmentation involves the inhibition of
tyrosinase, … This review focuses on the tyrosinase inhibition properties of a series of natural and …

Efficacy and tolerability of a depigmenting gel serum comprising tranexamic acid, niacinamide, 4‐butylresorcinol, phytic acid, and a mixture of hydroxy acids that …

M Furmanczyk, A Brown, J Bustos… - Journal of Cosmetic …, 2024 - Wiley Online Library
… and maintenance of pigmentation control after treatment termination.In vitro, MADV strongly
… al. 4- n- butylresorcinol, a highly effective tyrosinase inhibitor for the topical treatment of hy- …

Tyrosinase inhibitors from natural and synthetic sources as skin-lightening agents

MN Masum, K Yamauchi, T Mitsunaga - Reviews in Agricultural …, 2019 - jstage.jst.go.jp
Tyrosinase inhibitors with high efficacy and less adverse … pigmentation disorders as well
as skin-whitening effect. In this review, we focus on the recent advances of tyrosinase inhibitors